1523 Even though the women living around the seaside already had many sexual relations with the Portuguese, the female inhabitants of the mountain regions just married the pale skinned people from Spain. One example was a young woman from Kakaskasen Tomohon by the name of Lingkan Wene who married a Spanish Captain named Juan de Avedo. Later their son was given the name Mainalo Wula'an because he had clear round eyes (Indo Spanish). The marriage of Minahasa women with men from Spain was not liked by the Portuguese because the Portuguese assumed that the Spanish were gaining control over the Minahasa area.
1540 Europeans came to the area of North Sulawesi; the area was nominally subject to the Sultan of Ternate, who exacted tribute from the coast tribes and introduced the Muslim religion among some of the maritime inhabitants. When the Portuguese obtained power and influence in Ternate and made its Sultan their vassal, they also took possession of the Minahasa and established a factory in Wenang.
1541 The name Manado was placed on the world map by the cartographer Nicolas Desliens. At first it indicated the island Manarow (todays Manado Tua), however, when Wenang became the center of trade the name Manado indicated Wenang, making the island Manarow Manado Tua (Old Manado). Minahasa became important to the Spanish because of the rich soil and was used by the Spanish to plant coffee that came from South America, to be traded in China. For that reason Manado was developed to become the center of commerce for the Chinese traders who traded the coffee in China.